7-Amino-4-hydroxy-4-trifluoromethyl-3,4-dihydroquinolin-2(1H)-one
نویسندگان
چکیده
The title compound, C(10)H(9)F(3)N(2)O(2), was prepared by the reaction of m-phenyl-enediamine and ethyl 4,4,4-trifluoro-acetoacetate. In the crystal, inter-molecular C-H⋯ F, N-H⋯F, O-H⋯N and N-H⋯O inter-actions contribute to the crystal packing.
منابع مشابه
2-Hydroxy-2-trifluoromethyl-3,4-dihydro-2H-1-benzopyran-4-one
The heterocyclic ring in the title compound, C(10)H(7)F(3)O(3), has a half-boat conformation with the hy-droxy-bearing C atom lying 0.595 (3) Å out of the plane of the five remaining atoms (r.m.s. deviation = 0.022 Å) in the direction of the hy-droxy O atom. Linear supra-molecular chains along the a axis, sustained by O-H⋯O hydrogen bonds between the hy-droxy H and ketone O atoms, feature in th...
متن کاملStudies on new platelet aggregation inhibitors 1. Synthesis of 7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives.
A series of 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-ones were prepared and tested for platelet aggregation inhibitory effect, cardiotonic activity and chronotropic activity. These compounds appeared to show selective inhibitory activity against platelet aggregation. Among them, 6-(4-ethoxycarbonylpiperidino)-7-nitro-3,4-dihydroquinoline-2(1H)-one (22f) showed the most potent...
متن کامل1,3-Diphenyl-8-trifluoromethyl-1H-pyrazolo[3,4-b]quinoline
The 1H-pyrazolo-[3,4-b]quinoline (PQ) core of the title mol-ecule, C(23)H(14)F(3)N(3), is aromatic and essentially planar (r.m.s. deviation = 0.015 Å) and the two phenyl substituents at positions 1 and 3 are twisted relative to this fragment by 29.74 (7) and 25.63 (7)°, respectively. In the crystal, mol-ecules are arranged along the b axis into stacks via π-π inter-actions, with an inter-planar...
متن کاملSynthesis of some novel pyrazolo[3,4-d]pyrimidine derivatives as potential antimicrobial agents.
The reaction of 4-hydrazino-8-(trifluoromethyl)quinoline (2) with ethoxymethylenecyanoacetate afforded ethyl 5-amino-1-[8-(trifluoromethyl)quinolin-4-yl]-1H-pyrazole-4-carboxylate (3) and that with ethoxymethylenemalononitrile afforded 5-amino-1-[8-(trifluoromethyl)quinolin-4-yl]-1H-pyrazole-4-carbonitrile (5). Compounds 3 and 5 were hydrolyzed to get 5-amino-1-[8-(trifluoromethyl)quinolin-4-yl...
متن کامل4-(3-Fluorophenyl)-6-hydroxy-5-(thiophen-2-ylcarbonyl)-6-trifluoromethyl-1,3-diazinan-2-one
In the title compound, C(16)H(12)F(4)N(2)O(3)S, the pyrimidine ring adopts a half-chair conformation; the mean plane formed by the ring atoms excluding the C atom bonded to the thio-phen-2-ylcarbonyl group has an r.m.s. deviation of 0.059 Å. The dihedral angle between the benzene and thio-phene rings is 62.26 (7)°. The mol-ecular conformation is stabilized by an intra-molecular O-H⋯O hydrogen b...
متن کامل